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KMID : 1142020180530030189
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Blood Research
2018 Volume.53 No. 3 p.189 ~ p.197
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Clinical features and survival outcomes of patients with lymphoplasmacytic lymphoma, including non-IgM type, in Korea: a single-center experience
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Kang Ji-Hoon
Hong Jung-Yong
Suh Cheol-Won
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Abstract
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Background: The incidence of lymphoplasmacytic lymphoma (LPL) is lower in Asian than in Western populations. Few studies have described the clinical features and treatment outcomes of patients with LPL, including non-IgM LPL, in East Asia.
Methods: We retrospectively analyzed patients diagnosed with LPL at Asan Medical Center between January 2001 and March 2016. We evaluated the clinical features and survival outcomes of patients with LPL and non-IgM LPL and compared these data with those of patients with LPL/Waldenstrom’s macroglobulinemia (WM).
Results: The median age at diagnosis of patients with LPL was 61.5 years (range, 34?77 yr); most patients were male (91%). Approximately three-quarters of the 22 patients with LPL were in the low or intermediate risk groups according to the International Prognostic Scoring System for Waldenstrom’s Macroglobulinemia classification. The median follow-up duration was 75 months [95% confidence interval (CI), 48?102 mo], and the median overall survival (OS) was 81 months (95% CI, 0?167 mo). The number of patients in the non-IgM LPL group who exhibited extramedullary involvement was higher than in the LPL/WM group. OS of the LPL/WM group was improved compared with that of the non-IgM LPL group [median not reached vs. 10.0 mo (95% CI, 0?36.7); P=0.05].
Conclusion: We present a single-center experience of 22 patients with LPL, including a non-IgM co-hort, in Korea. The treatment of non-IgM LPL was heterogeneous, and patients with non-IgM LPL showed a higher 5-year mortality rate and more adverse prognostic factors than those with LPL/WM.
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KEYWORD
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Lymphoplasmacytic lymphoma, Non-IgM, Waldenstrom’s macroglobulinemia
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